(E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate

Base Information

Chemical Name:(E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate
CAS No.:1610702-01-6
Molecular Formula:C₁₁H₁₀Br₂O₄
Molecular Weight:366.006
Hs Code.:

Synonyms:(E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate

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Chemical Property of (E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate

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Technology Process of (E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate

There total 5 articles about (E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1428945-38-3
(E)-2,4-dihydroxy-6-(1-propenyl)benzoic acid methyl ester

: 1610702-01-6
(E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate

Guidance literature:: With N-Bromosuccinimide; In toluene; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo5008527

Reference yield:

: 83-30-7
acide 2,4,6-trihydroxybenzoique

: 1610702-01-6
(E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfate; potassium carbonate / acetone / 16 h / 20 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere; Reflux

2.1: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 48 h / 80 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 24 h / 45 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

5.1: N-Bromosuccinimide / toluene / 16 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; boron tribromide; potassium carbonate; dimethyl sulfate; lithium chloride; In tetrahydrofuran; dichloromethane; acetone; toluene; 2.1: |Stille Cross Coupling;
DOI:10.1021/jo5008527

Reference yield:

: 185038-86-2
4-Benzyloxy-2-methoxy-6-trifluoromethanesulfonyloxy-benzoic acid methyl ester

: 1610702-01-6
(E)-methyl 3,5-dibromo-4,6-dihydroxy-2-(prop-1-en-1-yl)-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 48 h / 80 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 24 h / 45 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

4: N-Bromosuccinimide / toluene / 16 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; boron tribromide; lithium chloride; In tetrahydrofuran; dichloromethane; toluene; 1: |Stille Cross Coupling;
DOI:10.1021/jo5008527