(S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one

Base Information

Chemical Name:(S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one
CAS No.:1352130-01-8
Molecular Formula:C₂₅H₂₅F₃N₄O₃
Molecular Weight:486.494
Hs Code.:

Synonyms:(S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one

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Chemical Property of (S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one

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Technology Process of (S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one

There total 18 articles about (S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 870852-75-8
(S,E)-1-(2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one

: 1352130-01-8
(S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one

Guidance literature:: (S,E)-1-(2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at -25 - -15 ℃; for 0.5h; Inert atmosphere;

With N-hydroxyphthalimide; In tetrahydrofuran; at -10 - 25 ℃; for 18h; Inert atmosphere;

With hydroxylamine; In tetrahydrofuran; water; at 25 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.joc.6b02979

Reference yield:

: 1352130-00-7
(S,E)-5-chloro-N-(2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl)-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)pentanamide

: 1352130-01-8
(S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -10 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol

With sodium methylate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; 2: Mitsunobu reaction;
DOI:10.1021/jm201407j

Reference yield:

: 1367361-09-8
C₁₆H₁₄F₃NO₃

: 1352130-01-8
(S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 20 % Pd(OH)2/C; hydrogen / methanol; water / 1 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: sodium methylate / methanol

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -10 - 20 °C / Inert atmosphere

5: hydrazine hydrate / ethanol

With 20 % Pd(OH)2/C; hydrogen; sodium methylate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; 4: Mitsunobu reaction;
DOI:10.1021/jm201407j