5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam

Base Information

Chemical Name:5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam
CAS No.:117097-25-3
Molecular Formula:C₂₂H₃₃NO₆Si
Molecular Weight:435.593
Hs Code.:

Synonyms:5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam

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Chemical Property of 5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam

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Technology Process of 5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam

There total 13 articles about 5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 125165-34-6
5-amino-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam

: 117097-25-3
5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1246/bcsj.65.978

Reference yield: 96.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 127181-02-6
5-amino-4-O-[(tert-butyl)dimethylsilyl]-5-deoxy-2,3-O-isopropylidene-D-ribono-1,5-lactam

: 117097-25-3,141781-90-0,141781-94-4
5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-D-1,5-ribonolactam

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1246/bcsj.65.978

Reference yield:

: 117097-24-2
5-azido-5-deoxy-2,3-O-isopropylidene-L-ribono-1,4-lactone

: 117097-25-3
5-N-(benzyloxycarbonyl)-4-O-(t-butyldimethylsilyl)-5-deoxy-2,3-O-isopropylidene-L-1,5-ribonolactam

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / H₂ / Raney Ni / methanol

2: 1.) imidazole, 2.) NaH / DMF

With 1H-imidazole; hydrogen; sodium hydride; nickel; In methanol;
DOI:10.1021/ja00229a069