(S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽²⁰⁾,16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Base Information

• Chemical Name: (S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽²⁰⁾,16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester
• CAS No.: 368871-36-7
• Molecular Formula: C₄₆H₆₅N₅O₁₀
• Molecular Weight: 848.05

Synonyms:(S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽²⁰⁾,16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Chemical Property of (S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽²⁰⁾,16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽²⁰⁾,16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester

There total 6 articles about (S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽²⁰⁾,16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-3-nitrohexanoic acid (367258-42-2) → (S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.17,10]henicosa-1(20),16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester (368871-36-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 66 percent / H₂; AcOH / Pd/C / 20 h / 20 °C / 3051.17 Torr

2: 89 percent / aq. NaOH / dioxane / 20 °C

3: 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; N-methylmorpholine / dimethylformamide / 16 h / 20 °C

4: aq. HCl / dioxane; ethyl acetate / 0.25 h / 20 °C

5: 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; N-methylmorpholine / dimethylformamide / 16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm050820s

Reference yield:

({2-[(3-amino-2-hydroxyhexanoyl)amino]acetyl}amino)(phenyl)acetic acid tert-butyl ester hydrochloride + 12-cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diazatricyclo[14.3.1.17,10]henicosa-1(19),16(20),17-triene-9-carboxylic acid (367259-03-8) → (S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.17,10]henicosa-1(20),16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester (368871-36-7)

Guidance literature:

With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jm050820s

Reference yield:

3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid (166196-06-1) → (S)-(2-{3-[((7R,9S,12S)-12-Cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diaza-tricyclo[14.3.1.17,10]henicosa-1(20),16,18-triene-9-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetylamino)-phenyl-acetic acid tert-butyl ester (368871-36-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; N-methylmorpholine / dimethylformamide / 16 h / 20 °C

2: aq. HCl / dioxane; ethyl acetate / 0.25 h / 20 °C

3: 3-hydroxy-1,2,3-benzotriazin-4(3H)-one; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; N-methylmorpholine / dimethylformamide / 16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm050820s

upstream raw materials:

12-cyclohexyl-5,5-dimethyl-11,14-dioxo-2,6-dioxa-10,13-diazatricyclo[14.3.1.1^7,10]henicosa-1⁽¹⁹⁾,16⁽²⁰⁾,17-triene-9-carboxylic acid

2-hydroxy-3-nitrohexanoic acid

3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid

[2-(3-tert-butoxycarbonylamino-2-hydroxy-hexanoylamino)-acetylamino]-phenyl-acetic acid tert-butyl ester

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