tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

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Chemical Name:tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate
CAS No.:757976-04-8
Molecular Formula:C₃₁H₄₂N₄O₅
Molecular Weight:550.698
Hs Code.:

Synonyms:tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

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Chemical Property of tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

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Technology Process of tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

There total 10 articles about tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 757976-56-0
N¹-((1S)-1-{[(4-hydroxyphenyl)amino]methyl}propyl)-N²-(5-phenylisoxazol-3-yl)-L-leucinamide

: 5292-43-3
bromoacetic acid tert-butyl ester

: 757976-04-8
tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2006.06.031

Reference yield:

: 313067-82-2
N-[4-(benzyloxy)phenyl]-2-nitrobenzenesulfonamide

: 757976-04-8
tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

Guidance literature:: Multi-step reaction with 5 steps

1: PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

2: PhSH; K₂CO₃ / acetonitrile / 20 °C

3: 1-hydroxy-1H-benzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; Et₃N / CH₂Cl₂

4: 56 percent / HCl; AcOH / 1 h / Heating

5: 56 percent / NaH / tetrahydrofuran; dimethylformamide / 1 h / 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; benzotriazol-1-ol; acetic acid; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2006.06.031

Reference yield:

: 757976-46-8
tert-butyl [(1S)-1-({[4-(benzyloxy)phenyl]amino}methyl)propyl]carbamate

: 757976-04-8
tert-butyl {4-[((2S)-2-{[N-(5-phenylisoxazol-3-yl)-L-leucyl]amino}butyl)amino]phenoxy}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-1H-benzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl; Et₃N / CH₂Cl₂

2: 56 percent / HCl; AcOH / 1 h / Heating

3: 56 percent / NaH / tetrahydrofuran; dimethylformamide / 1 h / 20 °C

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.031