2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate

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Chemical Name:2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate
CAS No.:1448724-04-6
Molecular Formula:C₂HF₃O₂*C₂₇H₃₁N₉
Molecular Weight:595.627
Hs Code.:

Synonyms:2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate

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Chemical Property of 2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate

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Technology Process of 2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate

There total 8 articles about 2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3529-08-6
1-(3-aminopropyl)piperidine

: 1448724-40-0
2-benzyl-4-chloro-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indole

: 76-05-1
trifluoroacetic acid

: 1448724-04-6
2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate

Guidance literature:: 1-(3-aminopropyl)piperidine; 2-benzyl-4-chloro-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indole; With triethylamine; In methanol; at 140 ℃; for 0.416667h; Microwave irradiation;

trifluoroacetic acid; In methanol; water;

Reference yield:

: 74308-41-1
5-(4′-fluorophenyl)-2-methyltetrazole

: 1448724-04-6
2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 3 h

3.1: iron(III) chloride hexahydrate; zinc / N,N-dimethyl-formamide; water / 1.25 h / 100 °C

4.1: sodium methylate / methanol / 1 h / 140 °C / Microwave irradiation

5.1: trichlorophosphate / 0.25 h / 175 °C / Microwave irradiation

6.1: triethylamine / methanol / 0.42 h / 140 °C / Microwave irradiation

With iron(III) chloride hexahydrate; sulfuric acid; nitric acid; sodium methylate; sodium hydride; triethylamine; zinc; trichlorophosphate; In methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1448724-36-4
5-(4-fluoro-3-nitrophenyl)-2-methyl-2H-tetrazole

: 1448724-04-6
2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-N-(3-(piperidin-1-yl)propyl)-9H-pyrimido[4,5-b]indol-4-amine 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 3 h

2.1: iron(III) chloride hexahydrate; zinc / N,N-dimethyl-formamide; water / 1.25 h / 100 °C

3.1: sodium methylate / methanol / 1 h / 140 °C / Microwave irradiation

4.1: trichlorophosphate / 0.25 h / 175 °C / Microwave irradiation

5.1: triethylamine / methanol / 0.42 h / 140 °C / Microwave irradiation

With iron(III) chloride hexahydrate; sodium methylate; sodium hydride; triethylamine; zinc; trichlorophosphate; In methanol; water; N,N-dimethyl-formamide; mineral oil;