N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine

Base Information

• Chemical Name: N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine
• CAS No.: 1227057-30-8
• Molecular Formula: C₁₉H₁₉NO
• Molecular Weight: 277.366
• Mol file: 1227057-30-8.mol

Synonyms:N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine

Chemical Property of N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine

Chemical Property:

Purity/Quality:

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Technology Process of N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine

There total 1 articles about N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

furfural (98-01-1) + 2-(1-phenylcyclohexa-2,5-dienyl)ethylamine (1227057-40-0) → N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine (1227057-30-8)

Guidance literature:

In toluene; for 26h; Inert atmosphere; Molecular sieve; Reflux;

DOI:10.1021/ol1004627

Reference yield: 53.0%

N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine (1227057-30-8) → rac-(1S,4aS,8aS)-1-(furan-2-yl)-4a-phenyl-1,2,3,4,4a,8a-hexahydroisoquinoline

Guidance literature:

N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - -50 ℃; for 3h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane; at -50 - 20 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol1004627

Reference yield: 45.0%

N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine (1227057-30-8) + acetic anhydride (108-24-7) → rac-(1S,4aS,8aS)-1-(1-(furan-2-yl)-4a-phenyl-1,4,4a,8a-tetrahydroisoquinolin-2(3H)-yl)ethanone

Guidance literature:

N-(furan-2-ylmethylene)-2-(1-phenylcyclohexa-2,5-dienyl)ethanamine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - -50 ℃; for 3h; Inert atmosphere;

acetic anhydride; In tetrahydrofuran; hexane; at -50 - 20 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol1004627

upstream raw materials:

furfural

2-(1-phenylcyclohexa-2,5-dienyl)ethylamine