6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one

Base Information

Chemical Name:6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one
CAS No.:1569066-06-3
Molecular Formula:C₂₀H₁₇FN₂O₄S
Molecular Weight:400.43
Hs Code.:

Synonyms:6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one

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Chemical Property of 6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one

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Technology Process of 6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one

There total 4 articles about 6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1342181-09-2
4-fluoro-2-((2-methoxyethoxy)methyl)benzothioamide

: 54903-10-5
6-(2-chloroacetyl)-2,3-dihydro-1,3-benzoxazol-2-one

: 1569066-06-3
6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one

Guidance literature:: With tetrabutylammomium bromide; In ethanol; at 85 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.05.067

Reference yield:

: 1569066-21-2
4-fluoro-2-((2-methoxyethoxy)methyl)benzonitrile

: 1569066-06-3
6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2: tetrabutylammomium bromide / ethanol / 18 h / 85 °C / Inert atmosphere

With sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; tetrabutylammomium bromide; In ethanol; N,N-dimethyl-formamide; 2: |Hantzsch Thiazole Synthesis;
DOI:10.1016/j.bmcl.2014.05.067

Reference yield:

: 421552-12-7
2-(bromomethyl)-4-fluorobenzonitrile

: 1569066-06-3
6-(2-(4-fluoro-2-((2-methoxyethoxy)methyl)phenyl)thiazol-4-yl)benzo[d]oxazol-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / -60 - 20 °C / Inert atmosphere

1.2: 3.5 h / -60 - 20 °C / Inert atmosphere

2.1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3.1: tetrabutylammomium bromide / ethanol / 18 h / 85 °C / Inert atmosphere

With sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; tetrabutylammomium bromide; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 3.1: |Hantzsch Thiazole Synthesis;
DOI:10.1016/j.bmcl.2014.05.067