tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate

Base Information

Chemical Name:tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate
CAS No.:1453267-80-5
Molecular Formula:C₂₅H₄₀ClN₃O₃Si
Molecular Weight:494.149
Hs Code.:

Synonyms:tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate

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Chemical Property of tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate

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Technology Process of tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate

There total 10 articles about tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 573768-09-9
4-amino-2-chloro-3-methyl-benzonitrile

: 1453267-37-2
tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-formylcyclopentyl)carbamate

: 1453267-80-5
tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate

Guidance literature:: 4-amino-2-chloro-3-methyl-benzonitrile; tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-formylcyclopentyl)carbamate; With acetic acid; In methanol; at 0 - 20 ℃;

With sodium cyanoborohydride; In methanol; at 0 ℃; for 16h;

Reference yield:

: 4065-92-3,86703-52-8
cyclopentane-1,2-diol

: 1453267-80-5
tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

1.2: 24 h / 20 °C

2.1: Jones reagent / acetone / 0 °C

3.1: ammonium chloride / water; ethanol / 15 h / 20 °C

3.2: 48 h / 100 °C

4.1: sodium hydroxide / 19 h / 100 °C / Sealed tube

4.2: 18 h / 20 °C

5.1: diethyl ether / 0.5 h / 0 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

7.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C

7.2: 0 - 20 °C

8.1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C

9.1: acetic acid / methanol / 0 - 20 °C

9.2: 16 h / 0 °C

With 1H-imidazole; Jones reagent; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; ammonium chloride; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 142-29-0
cyclopentene

: 1453267-80-5
tert-butyl (2-((tert-butyldimethylsilyl)oxy)-1-(((3-chloro-4-cyano-2-methylphenyl)amino)methyl)cyclopentyl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / toluene; acetone; water / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

2.2: 24 h / 20 °C

3.1: Jones reagent / acetone / 0 °C

4.1: ammonium chloride / water; ethanol / 15 h / 20 °C

4.2: 48 h / 100 °C

5.1: sodium hydroxide / 19 h / 100 °C / Sealed tube

5.2: 18 h / 20 °C

6.1: diethyl ether / 0.5 h / 0 °C

7.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

8.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 0 °C

8.2: 0 - 20 °C

9.1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C

10.1: acetic acid / methanol / 0 - 20 °C

10.2: 16 h / 0 °C

With 1H-imidazole; osmium(VIII) oxide; Jones reagent; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; ammonium chloride; acetic acid; 4-methylmorpholine N-oxide; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;