tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate

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Chemical Name:tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate
CAS No.:1000046-88-7
Molecular Formula:C₂₆H₃₈ClN₃O₅
Molecular Weight:508.058
Hs Code.:
Mol file:1000046-88-7.mol

Synonyms:tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate

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Chemical Property of tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate Edit

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Technology Process of tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate

There total 12 articles about tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000046-89-8
4-{(2S)-2-amino-2-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}-1-(2-chlorophenyl)-5,5-dimethylpiperazin-2-one

: 24424-99-5
di-tert-butyl dicarbonate

: 1000046-88-7
tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 145589-03-3,104266-90-2
(S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one

: 1000046-88-7
tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran; hexane / 1.25 h / -78 °C / Inert atmosphere

1.2: 5 h / -78 - -40 °C / Inert atmosphere

2.1: dihydrogen peroxide; lithium hydroxide monohydrate / tetrahydrofuran; water / 16.5 h / 0 - 20 °C

3.1: tetra(n-butyl)ammonium hydrogensulfate; Shi's ketone; Oxone; potassium carbonate; edetate disodium / acetonitrile / 9 h / 0 °C

4.1: triethylamine / dichloromethane / 3 h / 0 °C

5.1: sodium azide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 72 h / 60 °C

6.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; 1,4-dioxane / 6 h / 20 °C

7.1: triethylamine / tetrahydrofuran; water / 2 h / 0 °C

8.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.17 h / 0 °C

9.1: toluene / 1.5 h / 110 °C

10.1: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

11.1: triethylamine / dichloromethane / 15 h / 20 °C

With hydrogenchloride; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; Oxone; sodium azide; Shi's ketone; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hexamethyldisilazane; edetate disodium; potassium carbonate; caesium carbonate; thiophenol; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: |Shi Asymmetric Epoxidation / 8.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.03.022

Reference yield:

: 1000045-24-8
(2S,4E)-6-(benzyloxy)-2-isopropylhex-4-enoic acid

: 1000046-88-7
tert-butyl {(1S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: tetra(n-butyl)ammonium hydrogensulfate; Shi's ketone; Oxone; potassium carbonate; edetate disodium / acetonitrile / 9 h / 0 °C

2: triethylamine / dichloromethane / 3 h / 0 °C

3: sodium azide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 72 h / 60 °C

4: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; 1,4-dioxane / 6 h / 20 °C

5: triethylamine / tetrahydrofuran; water / 2 h / 0 °C

6: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.17 h / 0 °C

7: toluene / 1.5 h / 110 °C

8: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

9: triethylamine / dichloromethane / 15 h / 20 °C

With hydrogenchloride; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; Oxone; sodium azide; Shi's ketone; palladium 10% on activated carbon; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; edetate disodium; potassium carbonate; caesium carbonate; thiophenol; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1: |Shi Asymmetric Epoxidation / 6: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.03.022