trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:115802-56-7
Molecular Formula:C₂₇H₃₉NO₇
Molecular Weight:489.609
Hs Code.:

Synonyms:trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

There total 6 articles about trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 108134-73-2,115802-55-6
trans-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 115802-56-7
trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: In 1,4-dioxane; at 110 ℃; for 29h;
DOI:10.1016/S0040-4020(01)85107-3

Reference yield:

: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

: 115802-56-7
trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / benzene / 1. 30 deg C, 3/4 h, 2.) reflux, 3 h

2: 77 percent / anhydrous AlCl₃ / CH₂Cl₂ / 3 h / Heating

3: 88 percent / 90percent formic acid, formamide / 3.5 h / 185 - 190 °C

4: 80 percent / 40percent NaOH / ethanol / 2 h / Heating

5: 75 percent / 1.) 12M H₂SO₄ / 1.) reflux, 1.5 h, 2.) room temperature, 3.) reflux, 5 h

6: 77 percent / dioxane / 29 h / 110 °C

With sodium hydroxide; aluminium trichloride; formic acid; thionyl chloride; sulfuric acid; formamide; In 1,4-dioxane; ethanol; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)85107-3

Reference yield:

: 80235-74-1
N-(1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethyl)formamide

: 115802-56-7
trans-N-(2,2-diethoxyethyl)-3-(3,4-dimethoxyphenyl)-6,7,8-trimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 40percent NaOH / ethanol / 2 h / Heating

2: 75 percent / 1.) 12M H₂SO₄ / 1.) reflux, 1.5 h, 2.) room temperature, 3.) reflux, 5 h

3: 77 percent / dioxane / 29 h / 110 °C

With sodium hydroxide; sulfuric acid; In 1,4-dioxane; ethanol;
DOI:10.1016/S0040-4020(01)85107-3