(S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one

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Chemical Name:(S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one
CAS No.:878049-26-4
Molecular Formula:C₂₄H₃₂O₄S₂
Molecular Weight:448.648
Hs Code.:

Synonyms:(S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one

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Chemical Property of (S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one

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Technology Process of (S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one

There total 15 articles about (S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 878049-25-3
Acrylic acid (S)-1-{(R)-2-(1-ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-but-3-enyl ester

: 878049-26-4
(S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 8h; Heating;
DOI:10.1055/s-2005-922774

Reference yield:

: 878049-28-6
1-(oxiran-2-yl)pent-4-en-2-ol

: 878049-26-4
(S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / Ph₃P; DIAD / tetrahydrofuran

2: 95 percent / K₂CO₃ / methanol

3: 97 percent / DMAP; imidazole / dimethylformamide

4: 54 percent / n-BuLi; BF₃*Et₂O / tetrahydrofuran / -78 °C

5: 84 percent / PPTS / CH₂Cl₂

6: 99 percent / TBAF / tetrahydrofuran

7: 75 percent / Et₃N / CH₂Cl₂

8: 95 percent / PhCH=RuCH[(Mes)NCH₂CH₂N(Mes)](PCy₃)Cl₂ / CH₂Cl₂ / 8 h / Heating

With 1H-imidazole; dmap; n-butyllithium; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; triphenylphosphine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1055/s-2005-922774

Reference yield:

: tert-Butyl-dimethyl-((R)-1-(S)-1-oxiranylmethyl-but-3-enyloxy)-silane

: 878049-26-4
(S)-6-{(R)-2-(1-Ethoxy-ethoxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: H₂O / Jacobsen's (R,R)-(-)-Co(salen) catalyst / 20 °C

2: 54 percent / n-BuLi; BF₃*Et₂O / tetrahydrofuran / -78 °C

3: 84 percent / PPTS / CH₂Cl₂

4: 99 percent / TBAF / tetrahydrofuran

5: 75 percent / Et₃N / CH₂Cl₂

6: 95 percent / PhCH=RuCH[(Mes)NCH₂CH₂N(Mes)](PCy₃)Cl₂ / CH₂Cl₂ / 8 h / Heating

With n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; triethylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2005-922774