Technology Process of 8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione
There total 8 articles about 8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1.1: 93 percent / pyridine / CH2Cl2 / 2 h / -20 °C
2.1: LiCl / bis(triphenylphosphine)palladium chloride / dimethylformamide / 3.5 h / 90 °C
3.1: 758 mg / aq. Cl / 1 h / 20 °C
4.1: Pd(PPh3)4 / toluene / 0.5 h / 20 °C
4.2: 80 percent / NaHCO3 / toluene; H2O / 5 h / Heating
5.1: 99 percent / trifluoroacetic acid / CH2Cl2 / 1 h
6.1: 57 percent / K2CO3; NaI / acetonitrile / 90 °C
With
pyridine; chlorine; potassium carbonate; trifluoroacetic acid; sodium iodide; lithium chloride;
bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium(0);
In
dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
4.1: Suzuki coupling reaction;
DOI:10.1211/0022357011776388
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: aq. HBr / H2O; acetic acid / 6 h / 138 °C
2.1: 2.0 g / NaOH / H2O; tetrahydrofuran
3.1: 93 percent / pyridine / CH2Cl2 / 2 h / -20 °C
4.1: LiCl / bis(triphenylphosphine)palladium chloride / dimethylformamide / 3.5 h / 90 °C
5.1: 758 mg / aq. Cl / 1 h / 20 °C
6.1: Pd(PPh3)4 / toluene / 0.5 h / 20 °C
6.2: 80 percent / NaHCO3 / toluene; H2O / 5 h / Heating
7.1: 99 percent / trifluoroacetic acid / CH2Cl2 / 1 h
8.1: 57 percent / K2CO3; NaI / acetonitrile / 90 °C
With
pyridine; sodium hydroxide; hydrogen bromide; chlorine; potassium carbonate; trifluoroacetic acid; sodium iodide; lithium chloride;
bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile;
6.1: Suzuki coupling reaction;
DOI:10.1211/0022357011776388