8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione

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Chemical Name:8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione
CAS No.:369618-35-9
Molecular Formula:C₂₈H₃₄N₂O₃
Molecular Weight:446.59
Hs Code.:

Synonyms:8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione

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Chemical Property of 8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione

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Technology Process of 8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione

There total 8 articles about 8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 80827-62-9
8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione

: 369618-31-5
5-phenyl-3,4-dihydro-3-amino-2H-1-benzopyran

: 369618-35-9
8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; at 90 ℃;
DOI:10.1211/0022357011776388

Reference yield:

: 369618-23-5
5-hydroxy-3,4-dihydro-3-(tert-butoxycarbonylamino)-2H-1-benzopyran

: 369618-35-9
8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 93 percent / pyridine / CH₂Cl₂ / 2 h / -20 °C

2.1: LiCl / bis(triphenylphosphine)palladium chloride / dimethylformamide / 3.5 h / 90 °C

3.1: 758 mg / aq. Cl / 1 h / 20 °C

4.1: Pd(PPh₃)4 / toluene / 0.5 h / 20 °C

4.2: 80 percent / NaHCO₃ / toluene; H₂O / 5 h / Heating

5.1: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h

6.1: 57 percent / K₂CO₃; NaI / acetonitrile / 90 °C

With pyridine; chlorine; potassium carbonate; trifluoroacetic acid; sodium iodide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Suzuki coupling reaction;
DOI:10.1211/0022357011776388

Reference yield:

: 110927-03-2
(R)-3-amino-5-methoxy-3,4dihydro-2H-1-benzopyran

: 369618-35-9
8-[N-(5-phenyl-3,4-dihydro-2H-1-benzopyran-3-yl)aminobutyl]-8-azaspiro[4,5]decane-7,9-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: aq. HBr / H₂O; acetic acid / 6 h / 138 °C

2.1: 2.0 g / NaOH / H₂O; tetrahydrofuran

3.1: 93 percent / pyridine / CH₂Cl₂ / 2 h / -20 °C

4.1: LiCl / bis(triphenylphosphine)palladium chloride / dimethylformamide / 3.5 h / 90 °C

5.1: 758 mg / aq. Cl / 1 h / 20 °C

6.1: Pd(PPh₃)4 / toluene / 0.5 h / 20 °C

6.2: 80 percent / NaHCO₃ / toluene; H₂O / 5 h / Heating

7.1: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h

8.1: 57 percent / K₂CO₃; NaI / acetonitrile / 90 °C

With pyridine; sodium hydroxide; hydrogen bromide; chlorine; potassium carbonate; trifluoroacetic acid; sodium iodide; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile; 6.1: Suzuki coupling reaction;
DOI:10.1211/0022357011776388