(2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate
CAS No.:1223020-37-8
Molecular Formula:C₁₈H₁₇ClN₂O₄
Molecular Weight:360.797
Hs Code.:

Synonyms:(2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Suppliers and Price of (2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

There total 4 articles about (2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 102-96-5
(2-nitroethenyl)benzene

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 1223020-37-8
(2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Guidance literature:: With (R,Sp)-ThioClickFerrophos; silver(I) acetate; In 1,4-dioxane; at 20 ℃; for 10h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2015.08.002

Reference yield: 36.0%

: 102-96-5
(2-nitroethenyl)benzene

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 1223020-37-8
(2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

: C₁₈H₁₇ClN₂O₄

Guidance literature:: With C₃₆H₃₆FeN₃PS; silver(I) acetate; triethylamine; In dichloromethane; at 0 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.07.085

Reference yield:

: 102-96-5
(2-nitroethenyl)benzene

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 1223020-37-8
(2S,3R,4S,5S)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

: 1257558-71-6
(2S,3R,4S,5R)-methyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Guidance literature:: With 2-{[(1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamino]methyl}-4,6-dibromophenol; nickel(II) acetate tetrahydrate; potassium carbonate; In acetonitrile; at -10 ℃; for 43h; optical yield given as %ee; stereoselective reaction;
DOI:10.1002/anie.201004098