(S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one

Base Information

• Chemical Name: (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one
• CAS No.: 630131-47-4
• Molecular Formula: C₂₀H₂₇N₃O₅S
• Molecular Weight: 421.517

Synonyms:(S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one

Chemical Property of (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one

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Technology Process of (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one

There total 2 articles about (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl (7-hydroxy-1,1-DIOXO-1,4-dihydrobenzo[1,2,4]thiadiazin-3-yl) acetate + (S)-α-Methylvaline (4378-19-2,26287-62-7,53940-82-2,53940-83-3) → (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one (630131-47-4)

Guidance literature:

Reference yield:

(R)-2-amino-2,3-dimethylbutanoic acid (53940-82-2) → (S)-4-hydroxy-3-(7-hydroxy-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-5-methyl-1-(3-methylbutyl)-5-(1-methylethyl)-1,5-dihydropyrrol-2-one (630131-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium cyanoborohydride / methanol / 48 h / 20 °C

1.2: sulfuric acid / 24 h / Heating

2.1: dicyclohexylcarbodiimide / CH₂Cl₂; dimethylformamide / 20 °C

2.2: 71 percent / triethylamine / CH₂Cl₂; dimethylformamide / 20 °C

With sodium cyanoborohydride; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide; 2.2: Dieckmann cyclization;

DOI:10.1021/ol052371w

upstream raw materials:

(R)-2-amino-2,3-dimethylbutanoic acid

(S)-α-Methylvaline

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