Technology Process of (2R,3'S,5'S,6'S,4''S)-2,N-dimethyl-N-[3',5',6'-trimethyl-7'-oxo-7'-(2''-oxo-4''-phenyloxazolidin-3-yl)heptyl]butyramide
There total 9 articles about (2R,3'S,5'S,6'S,4''S)-2,N-dimethyl-N-[3',5',6'-trimethyl-7'-oxo-7'-(2''-oxo-4''-phenyloxazolidin-3-yl)heptyl]butyramide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
DOI:10.1039/b404205k
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 74 percent / NBS; PPh3 / CH2Cl2 / 0.17 h / 20 °C
2: 100 percent / H2 / Pd(OH)2 / ethyl acetate / 2 h
3: 85 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.75 h / -78 - 0 °C
4: Na2SO4 / methanol; tetrahydrofuran / 0.33 h / 20 °C
5: 0.314 g / NaCNBH3 / methanol / 1 h / 20 °C
6: 84 percent / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; (i-Pr)2NEt / dimethylformamide / 12 h / 20 °C
With
N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; hydrogen; sodium cyanoborohydride; dimethyl sulfoxide; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
4: Swern oxidation;
DOI:10.1039/b404205k
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / H2 / Pd(OH)2 / ethyl acetate / 2 h
2: 85 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.75 h / -78 - 0 °C
3: Na2SO4 / methanol; tetrahydrofuran / 0.33 h / 20 °C
4: 0.314 g / NaCNBH3 / methanol / 1 h / 20 °C
5: 84 percent / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; (i-Pr)2NEt / dimethylformamide / 12 h / 20 °C
With
1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; hydrogen; sodium cyanoborohydride; dimethyl sulfoxide; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
2: Swern oxidation;
DOI:10.1039/b404205k
