4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol

Base Information

• Chemical Name: 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol
• CAS No.: 1203604-12-9
• Molecular Formula: C₁₈H₁₅N₅OS
• Molecular Weight: 349.416
• Mol file: 1203604-12-9.mol

Synonyms:4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol

Chemical Property of 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol

There total 1 articles about 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

4-(3-chloro-1,2,4-triazin-5-yl)-3-methylphenol (1203605-18-8) + 1,3-benzothiazol-2-ylmethanamine (42182-65-0) → 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol (1203604-12-9)

Guidance literature:

With pyridine; In acetonitrile; at 85 ℃;

Reference yield: 7.0%

4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol (1203604-12-9) + methyloxirane (75-56-9,16033-71-9) → 1-(4-{3-[(1,3-benzothiazol-2-ylmethyl)aminol]-1,2,4-triazin-5-yl}-3-methylphenoxy)propan-2-ol (1203604-13-0)

Guidance literature:

4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol; With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 1h; Inert atmosphere;

methyloxirane; In N,N-dimethyl-formamide; at 50 ℃;

upstream raw materials:

4-(3-chloro-1,2,4-triazin-5-yl)-3-methylphenol

1,3-benzothiazol-2-ylmethanamine

Downstream raw materials:

1-(4-{3-[(1,3-benzothiazol-2-ylmethyl)aminol]-1,2,4-triazin-5-yl}-3-methylphenoxy)propan-2-ol