methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate

Base Information

Chemical Name:methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate
CAS No.:922529-70-2
Molecular Formula:C₃₂H₃₃F₃N₄O₇
Molecular Weight:642.632
Hs Code.:

Synonyms:methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate

Suppliers and Price of methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate

There total 6 articles about methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 922529-69-9
methyl 3-amino-4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxybenzoate

: 407-25-0
trifluoroacetic anhydride

: 922529-70-2
methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1248/cpb.54.1515

Reference yield:

: 922529-36-0
methyl 3-nitro-4-[(2S)-pyrrolidinyl]methoxybenzoate

: 922529-70-2
methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: EDC*HCl; HOBt; DMAP / dimethylformamide / 12 h / 20 °C

2: 69 percent / SnCl₂*2H₂O / ethanol / 1 h / Heating

3: 74 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tin(ll) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.54.1515

Reference yield:

: 922529-65-5
methyl 4-[1-(tert-butoxycarbonyl)-(2S)-pyrrolidinyl]methoxy-3-nitrobenzoate

: 922529-70-2
methyl 4-[1-[3-methoxy-4-[N-(2-methylphenyl)ureido]phenylacetyl]-(2S)-pyrrolidinyl]methoxy-3-trifluoroacetylaminobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / TFA / CH₂Cl₂ / 48 h / 20 °C

2: EDC*HCl; HOBt; DMAP / dimethylformamide / 12 h / 20 °C

3: 69 percent / SnCl₂*2H₂O / ethanol / 1 h / Heating

4: 74 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; tin(ll) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.54.1515