(E)-tert-butyl 3-(2,3,5,6-tetrafluoro-4-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)phenyl)acrylate

Base Information

Chemical Name:(E)-tert-butyl 3-(2,3,5,6-tetrafluoro-4-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)phenyl)acrylate
CAS No.:1358531-75-5
Molecular Formula:C₂₃H₁₉F₄NO₃
Molecular Weight:433.402
Hs Code.:

Synonyms:(E)-tert-butyl 3-(2,3,5,6-tetrafluoro-4-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)phenyl)acrylate

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Chemical Property of (E)-tert-butyl 3-(2,3,5,6-tetrafluoro-4-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)phenyl)acrylate

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Technology Process of (E)-tert-butyl 3-(2,3,5,6-tetrafluoro-4-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)phenyl)acrylate

There total 2 articles about (E)-tert-butyl 3-(2,3,5,6-tetrafluoro-4-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 83-54-5
1-methyl-4-quinolone

: C₁₃H₁₂F₄O₂

: 1358531-75-5
(E)-tert-butyl 3-(2,3,5,6-tetrafluoro-4-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)phenyl)acrylate

Guidance literature:: With diisopropylsulfide; palladium diacetate; silver carbonate; In 1,4-dioxane; at 140 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol300240k

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 327-54-8
1,2,4,5-Tetrafluorobenzene

: 1358531-75-5
(E)-tert-butyl 3-(2,3,5,6-tetrafluoro-4-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; silver carbonate; Trimethylacetic acid / N,N-dimethyl-formamide / 120 °C / Inert atmosphere

2: diisopropylsulfide; palladium diacetate; silver carbonate / 1,4-dioxane / 140 °C / Inert atmosphere

With diisopropylsulfide; palladium diacetate; silver carbonate; Trimethylacetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/ol300240k