isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Base Information

Chemical Name:isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate
CAS No.:1454555-37-3
Molecular Formula:C₂₁H₂₄FN₅O₃
Molecular Weight:413.452
Hs Code.:

Synonyms:isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

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Chemical Property of isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

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Technology Process of isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

There total 4 articles about isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454558-23-6
4-(3-bromo-pyrazolo[1,5-a]pyrimidin-5-yl)-piperazine-1-carboxylic acid isopropyl ester

: 179897-94-0
(5-fluoro-2-methoxyphenyl)boronic acid

: 1454556-63-8
isopropyl 4-(pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

: 1454555-37-3
isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Guidance literature:: With palladium diacetate; potassium carbonate; XPhos; In 1,4-dioxane; water; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 960613-96-1
3-bromo-5-chloro-pyrazolo[1,5-a]pyrimidine

: 1454556-63-8
isopropyl 4-(pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

: 1454555-37-3
isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2 h / Inert atmosphere; Heating

2: N-ethyl-N,N-diisopropylamine / ethyl acetate; toluene / 0 - 20 °C / Inert atmosphere

3: potassium carbonate; palladium diacetate; XPhos / water; 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In 1,4-dioxane; water; ethyl acetate; toluene;

Reference yield:

: 29274-24-6
5-chloropyrazolo[1,5-a]pyrimidine

: 1454556-63-8
isopropyl 4-(pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

: 1454555-37-3
isopropyl 4-(3-(5-fluoro-2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; acetic acid / 20 °C

1.2: 0.83 h / 0 °C

2.1: 2 h / Inert atmosphere; Heating

3.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; toluene / 0 - 20 °C / Inert atmosphere

4.1: potassium carbonate; palladium diacetate; XPhos / water; 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

With sodium acetate; palladium diacetate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; XPhos; In 1,4-dioxane; water; ethyl acetate; toluene;