3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Base Information

Chemical Name:3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
CAS No.:944704-71-6
Molecular Formula:C₂₅H₂₁F₃N₂O₂S
Molecular Weight:470.515
Hs Code.:

Synonyms:3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

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Chemical Property of 3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

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Technology Process of 3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

There total 4 articles about 3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90357-51-0
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

: 944704-71-6
3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Guidance literature:: 2-mercaptodiphenylmethane; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 120454-34-4
2-mercaptodiphenylmethane

: 90357-51-0
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

: 944704-71-6
3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Guidance literature:: 2-mercaptodiphenylmethane; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ja0701154

Reference yield:

: 28059-64-5
2-benzylaniline

: 944704-71-6
3-(2-benzylphenylthio)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. HCl; aq. NaNO₂ / 0.25 h

1.2: H₂O / 0.5 h / 45 °C

2.1: KOH / ethanol / Heating

3.1: NaH / tetrahydrofuran / 0.08 h / 0 °C

3.2: 56 mg / tetrahydrofuran / 20 °C

With hydrogenchloride; potassium hydroxide; sodium hydride; sodium nitrite; In tetrahydrofuran; ethanol;
DOI:10.1021/ja0701154