(S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylpropanamide

Base Information

• Chemical Name: (S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylpropanamide
• CAS No.: 1092698-85-5
• Molecular Formula: C₂₅H₂₅BrClNO₂
• Molecular Weight: 486.836
• Mol file: 1092698-85-5.mol

Synonyms:(S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylpropanamide

Chemical Property of (S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylpropanamide

There total 1 articles about (S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(3-bromophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylacetamide (1092698-84-4) + 4-chlorobenzyl bromide (622-95-7) → (S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylpropanamide (1092698-85-5)

Guidance literature:

2-(3-bromophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylacetamide; With lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; at -15 ℃; for 1h;

4-chlorobenzyl bromide; In tetrahydrofuran; at 20 ℃; for 3h; Further stages.;

DOI:10.1016/j.tet.2008.09.057

Reference yield: 70.0%

(S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylpropanamide (1092698-85-5) → (S)-2-(3-bromophenyl)-3-(4-chlorophenyl)-propionic acid

Guidance literature:

With sulfuric acid; In 1,4-dioxane; for 2h; Heating;

DOI:10.1016/j.tet.2008.09.057

upstream raw materials:

2-(3-bromophenyl)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N-methylacetamide

4-chlorobenzyl bromide