N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide

Base Information

Chemical Name:N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide
CAS No.:61807-88-3
Molecular Formula:C₂₈H₂₂Cl₂N₄O₄
Molecular Weight:549.413
Hs Code.:

Synonyms:N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide

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Chemical Property of N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide

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Technology Process of N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide

There total 8 articles about N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 57963-14-1
N-<<2-(aminomethyl)-1,3-dioxolan-2-yl>methyl>phthalimide

: 2894-71-5,49853-64-7
7-chloro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione

: 61807-88-3
N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide

Guidance literature:: In ethanol; at 60 ℃; for 18h;
DOI:10.1021/jo00321a010

Reference yield: 10.0%

: 67974-55-4
7-Chloro-5-(2-chloro-phenyl)-2-ethylsulfanyl-3H-benzo[e][1,4]diazepine

: 57963-14-1
N-<<2-(aminomethyl)-1,3-dioxolan-2-yl>methyl>phthalimide

: 76879-41-9
C₁₃H₁₂N₂O₃

: 76879-39-5
C₂₁H₁₆N₂O₆

: 61807-88-3
N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide

Guidance literature:: In butan-1-ol; for 18h; Heating;
DOI:10.1021/jo00321a010

Reference yield:

: 1775-18-4
N-(2-methyl-[1,3]dioxolan-2-ylmethyl)-phthalimide

: 61807-88-3
N-<<2-<<7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl>amino>methyl>-1,3-dioxolan-2-yl>methylphthalimide

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / Br₂ / ethane-1,2-diol / Heating

2: 95 percent / NaN₃ / dimethylsulfoxide / 100 h / 100 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 2.5 h / 2585.7 Torr / Ambient temperature

4: 84 percent / ethanol / 18 h / 60 °C

With sodium azide; hydrogen; bromine; palladium on activated charcoal; In ethanol; ethylene glycol; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00321a010