3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoic acid

Base Information

Chemical Name:3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoic acid
CAS No.:25379-26-4
Molecular Formula:C18H20 O3
Molecular Weight:284.355
Hs Code.:2932190090
European Community (EC) Number:246-926-0
DSSTox Substance ID:DTXSID20948218
Nikkaji Number:J109.281B
Mol file:25379-26-4.mol

Synonyms:naphthidrofurylic acid

Suppliers and Price of 3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoicAcid
2.5g
$ 1080.00

TRC
Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoicAcid
250mg
$ 180.00

Crysdot
3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoicacid 95+%
1g
$ 280.00

Chemenu
3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoicacid 95%
10g
$ 468.00

Chemenu
3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoicacid 95%
5g
$ 281.00

Alichem
3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoicacid
10g
$ 490.00

AHH
1-(Tetrahydro-2-furyl)-3-(1-naphthyl)propane-2-carboxylicacid 98%
25g
$ 430.00

Total 44 raw suppliers

Chemical Property of 3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoic acid

Chemical Property:

Vapor Pressure:2.04E-09mmHg at 25°C
Boiling Point:464.2°C at 760 mmHg
PKA:4.44±0.11(Predicted)
Flash Point:169.1°C
PSA：46.53000
Density:1.183g/cm³
LogP:3.65220
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:DMSO (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:284.14124450
Heavy Atom Count:21
Complexity:354

Purity/Quality:

99.9% ^*data from raw suppliers

Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(OC1)CC(CC2=CC=CC3=CC=CC=C32)C(=O)O
Uses Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic Acid is a Nafronyl (N215000) derivative. Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.

Technology Process of 3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoic acid

There total 54 articles about 3-(Naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 113527-39-2,115025-90-6
1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2,2-dicarboxylic acid

: 25379-26-4
acide 2-<(naphth-1-yl)methyl>-3-(tetrahydrofur-2-yl)propanoique

Guidance literature:: 1.) 140 deg C, 1 h, 2.) 160 deg C, 1 h.;

Reference yield: 23.0%

: 1392400-74-6
2-[(naphthalen-1-yl)methyl]-3-[(S)-tetrahydrofuran-2-yl]propanoic acid

: 25379-26-4,115025-92-8,115025-93-9,139240-21-4,139240-22-5,139240-23-6,139240-20-3
(2R,2'S)-acide 2-<(naphth-1-yl)methyl>-3-(tetrahydrofur-2-yl)propanoique

Guidance literature:: 2-[(naphthalen-1-yl)methyl]-3-[(S)-tetrahydrofuran-2-yl]propanoic acid; With (S)-1-phenyl-ethylamine; In diethyl ether; at 20 ℃; for 1h;

With hydrogenchloride; In water; at 0 ℃; pH=1; Further stages;
DOI:10.1016/j.bmcl.2012.03.093

Reference yield:

: 98-01-1
furfural

: 25379-26-4
acide 2-<(naphth-1-yl)methyl>-3-(tetrahydrofur-2-yl)propanoique

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / piperidine, acetic acid / toluene / 1.) 100-104 deg C, 1.5 h, 2.) 110-120 deg C, 4 h.

2: 88 percent / hydrogen / Raney Ni / ethanol / 6 h / 80 °C / 56254.5 Torr

3: 76 percent / sodium ethoxide / ethanol

4: 60 percent / 85percent KOH / H₂O; ethanol / 3 h / Heating

5: 96 percent / 1.) 140 deg C, 1 h, 2.) 160 deg C, 1 h.

With piperidine; potassium hydroxide; hydrogen; sodium ethanolate; acetic acid; nickel; In ethanol; water; toluene;