6-Chloro-9-(beta-D-arabinofuranosyl)purine

Base Information

• Chemical Name: 6-Chloro-9-(beta-D-arabinofuranosyl)purine
• CAS No.: 7596-60-3
• Molecular Formula: C10H11ClN4O4
• Molecular Weight: 286.675
• Mol file: 7596-60-3.mol

Synonyms:2-(6-chloropurin-9-yl)-5-hydroxymethyltetrahydrofuran-3,4-diol;

Chemical Property of 6-Chloro-9-(beta-D-arabinofuranosyl)purine

Chemical Property:

• PSA: 113.52000
• Density: 2.03
• LogP: -0.90880
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

9-b-D-arabinofuranosyl-6-chloro-9H-Purine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-9-(beta-D-arabinofuranosyl)purine

There total 3 articles about 6-Chloro-9-(beta-D-arabinofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(6-chloropurin-9-yl)-5-hydroxymethyltetrahydrofuran-3,4-diol (2004-06-0,5399-87-1,7596-60-3,23828-03-7)

Guidance literature:

aus Inosin;

Reference yield:

9-β-D-arabinofuranosylguanine (38819-10-2) + 6-chloropurine (87-42-3) → arabinosyl 6-chloropurine (7596-60-3)

Guidance literature:

With purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei; In aq. phosphate buffer; at 50 ℃; for 4h; pH=6; Enzymatic reaction;

DOI:10.1002/cctc.201800775

Reference yield:

9-β-D-arabinofuranosylguanine (38819-10-2) → arabinosyl 6-chloropurine (7596-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei / aq. phosphate buffer / 4 h / 50 °C / pH 6 / Enzymatic reaction

2: purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei / aq. phosphate buffer / 4 h / 50 °C / pH 6 / Enzymatic reaction

With purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei; In aq. phosphate buffer;

DOI:10.1002/cctc.201800775

upstream raw materials:

9-β-D-arabinofuranosylguanine

6-chloropurine

Downstream raw materials:

6-thio-inosine

Refernces

• 1、 Sugiyama,Hashizume. "Ribosylation of 6-chloropurine and its 2-methylthio derivative by a fusion procedure using iodine". . p. 1791 - 1792. Retrieved 2007/10/10.