L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester

Base Information

Chemical Name:L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester
CAS No.:105189-65-9
Molecular Formula:C₂₇H₂₅F₃I₂N₂O₅S
Molecular Weight:800.376
Hs Code.:

Synonyms:L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester

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Chemical Property of L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester

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Technology Process of L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester

There total 12 articles about L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 105189-65-9
L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester

Guidance literature:

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 105189-65-9
L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1) n-BuLi / 1) THF, hexane, -85 deg C, 5 min, 2) THF, below -70 deg C to room temperature

2: pyridine / 50 °C

3: H₂ / 10percent Pd/C / methanol

4: 55 percent / Ac₂O, Cl₂ / acetic acid / 20 h / Ambient temperature

5: 2.55 g / NaOH / dioxane; H₂O / 5 h / Heating

6: 1) Me₂SO₂Cl, pyridine, 2) pyridine / 1) reflux, 10 min, 2) reflux, 20 min

7: H₂ / 10percent Pd/C / acetic acid

8: 1) NaNO₂, H₂SO₄, 2) KI, I₂

With pyridine; sodium hydroxide; n-butyllithium; Me₂SO₂Cl; sulfuric acid; hydrogen; iodine; acetic anhydride; chlorine; potassium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; methanol; water; acetic acid;
DOI:10.1021/jm00122a009

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 105189-65-9
L-3,5-diiodo-4-(4'-methoxy-3'-(6-methoxy-3-pyridylmethyl)-phenylthio)-N-trifluoracetyl phenylalanine ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1) n-BuLi / 1) THF, hexane, -85 deg C, 5 min, 2) THF, below -70 deg C to room temperature

2: pyridine / 50 °C

3: H₂ / 10percent Pd/C / methanol

4: 55 percent / Ac₂O, Cl₂ / acetic acid / 20 h / Ambient temperature

5: 2.55 g / NaOH / dioxane; H₂O / 5 h / Heating

6: 1) Me₂SO₂Cl, pyridine, 2) pyridine / 1) reflux, 10 min, 2) reflux, 20 min

7: H₂ / 10percent Pd/C / acetic acid

8: 1) NaNO₂, H₂SO₄, 2) KI, I₂

With pyridine; sodium hydroxide; n-butyllithium; Me₂SO₂Cl; sulfuric acid; hydrogen; iodine; acetic anhydride; chlorine; potassium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; methanol; water; acetic acid;
DOI:10.1021/jm00122a009