[2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate

Base Information

• Chemical Name: [2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate
• CAS No.: 251995-69-4
• Molecular Formula: C₂₀H₃₁NO₃
• Molecular Weight: 333.471
• Mol file: 251995-69-4.mol

Synonyms:[2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate

Chemical Property of [2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate

There total 11 articles about [2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

n-butyllithium (109-72-8,29786-93-4) + [2R-(2S)]-1-benzyloxycarbonyl-2-(2,3-epoxypropyl)piperidine (190383-57-4) → [2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate (251995-69-4)

Guidance literature:

With copper(l) iodide; In diethyl ether; at -70 ℃; for 2h;

DOI:10.1021/jo991034w

Reference yield:

[1-(toluene-4-sulfonyl)-piperidin-2-yl]-acetaldehyde (934472-12-5) → [2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate (251995-69-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 percent / tetrahydrofuran; diethyl ether / 6 h / -78 - 20 °C

2: Na; naphthalene / tetrahydrofuran / 2 h / 0 - 20 °C

3: NaHCO₃ / tetrahydrofuran / 2 h

With naphthalene; sodium; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.tetlet.2007.01.082

Reference yield:

(R)-N-tosyl-2-piperidinylethanol (934472-11-4) → [2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate (251995-69-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / (COCl)2; DMSO; Et₃N / 8 h / -78 - 20 °C

2: 32 percent / tetrahydrofuran; diethyl ether / 6 h / -78 - 20 °C

3: Na; naphthalene / tetrahydrofuran / 2 h / 0 - 20 °C

4: NaHCO₃ / tetrahydrofuran / 2 h

With oxalyl dichloride; naphthalene; sodium; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.tetlet.2007.01.082

upstream raw materials:

n-butyllithium

[2R-(2S)]-1-benzyloxycarbonyl-2-(2,3-epoxypropyl)piperidine

benzyl chloroformate

(R)-(R)-1-Piperidin-2-yl-heptan-2-ol

Downstream raw materials:

[2R-(2S)]-phenylmethyl 2-(2-(2,5-dioxopyrrolidinyl)heptyl)piperidinecarboxylate