(2s,3R)-3-Methylglutamic acid

Base Information

• Chemical Name: (2s,3R)-3-Methylglutamic acid
• CAS No.: 33511-69-2
• Molecular Formula: C₆H₁₁NO₄
• Molecular Weight: 161.158
• Mol file: 33511-69-2.mol

Synonyms:(2S,3R)-2-amino-3-methylpentanedioic acid

Chemical Property of (2s,3R)-3-Methylglutamic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(2S,3R)-3-METHYLGLUTAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2s,3R)-3-Methylglutamic acid

There total 39 articles about (2s,3R)-3-Methylglutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2S,3R)-2-Dibenzylamino-3-methyl-pentanedioic acid (129397-27-9) → (+/-)-threo-3-methylglutamate (2445-97-8,6070-75-3,6208-94-2,33511-69-2,33511-70-5,63088-04-0,76318-75-7,97550-61-3,274255-87-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃; for 0.5h;

DOI:10.1246/cl.1990.377

Reference yield: 52.0%

(4S,5S)-4-methyl-5-(4-methyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)-pyrrolidin-2-one → (2S,3R)-2-amino-3-methylpentanedioic acid (33511-69-2,274255-87-7)

Guidance literature:

With hydrogenchloride; In water; for 6h; Heating;

DOI:10.1016/S0040-4020(02)01490-4

Reference yield: 46.0%

dilithium 3-methyl-2-oxoglutarate → (2S,3R)-2-amino-3-methylpentanedioic acid (33511-69-2,274255-87-7)

Guidance literature:

With cysteinesulfinic acid; Escherichia coli aspartate aminotransferase; In water; at 20 ℃; for 32h; pH=7.6; Enzymatic reaction;

DOI:10.1021/jo070805q

upstream raw materials:

(2S,3R)-2-Dibenzylamino-3-methyl-pentanedioic acid

(2R,3S)-2-Dibenzylamino-3-methyl-pentanedioic acid di-tert-butyl ester

C₅₃H₈₃N₁₁O₂₀

N-MePhe-N-MeAsn-HyGln-MeGlu