ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate

Base Information

Chemical Name:ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate
CAS No.:170282-65-2
Molecular Formula:C₂₇H₂₇NO₅S
Molecular Weight:477.581
Hs Code.:

Synonyms:ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate

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Chemical Property of ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate

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Technology Process of ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate

There total 6 articles about ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 170282-62-9
ethyl (RS)-4-[2-(4,5-dihydrooxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate

: 170282-65-2
ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate

Guidance literature:: With nickel(IV) oxide; In toluene; at 100 ℃; for 24h;
DOI:10.1021/jm9707131

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 170282-65-2
ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / TiCl₄ / CH₂Cl₂ / 2 h / Ambient temperature

2: NaH / tetrahydrofuran

3: (methoxycarbonylsulfamoyl)triethylammonium hydroxide / tetrahydrofuran / 0.5 h / Heating

4: 16 percent / NiO₂ / toluene / 24 h / 100 °C

With nickel(IV) oxide; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; titanium tetrachloride; sodium hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm9707131

Reference yield:

: 170283-15-5
ethyl (RS)-4-chloro-4-(2-methylphenyl)butanoate

: 170282-65-2
ethyl (RS)-4-[2-(oxazol-2-yl)-5-(thien-3-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran

2: (methoxycarbonylsulfamoyl)triethylammonium hydroxide / tetrahydrofuran / 0.5 h / Heating

3: 16 percent / NiO₂ / toluene / 24 h / 100 °C

With nickel(IV) oxide; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1021/jm9707131