N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

Base Information

Chemical Name:N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine
CAS No.:177086-06-5
Molecular Formula:C₃₅H₅₂FNO₁₁
Molecular Weight:681.796
Hs Code.:

Synonyms:N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

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Chemical Property of N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

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Technology Process of N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

There total 6 articles about N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.3%

: 41355-50-4,51642-81-0,58484-22-3,70128-27-7,70145-20-9,94482-21-0,98300-76-6
2,3,4,6-tetra-O-acetyl-D-glucosyl-1-amine

: (+/-)-threo-3-benzyloxy-2-fluorotetradecanoyl chloride

: 177086-06-5
N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

: 177314-20-4
N-[(2S,3R)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 24 ℃; for 15h;
DOI:10.1246/bcsj.70.1149

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 177086-06-5
N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / 16 h / 25 °C

2: 60 percent / NaOH / ethanol; H₂O / 2 h / 50 °C

3: oxalyl chloride / CH₂Cl₂ / 1 h / 24 °C

4: 37.8 percent / triethylamine / CH₂Cl₂ / 15 h / 0 - 24 °C

With sodium hydroxide; oxalyl dichloride; trifluorormethanesulfonic acid; triethylamine; In ethanol; dichloromethane; water; 1: Etherification / 2: Hydrolysis / 3: Chlorination / 4: Acylation;
DOI:10.1246/bcsj.70.1149

Reference yield:

: (+/-)-methyl threo-2-fluoro-3-hydroxytetradecanoate

: 177086-06-5
N-[(2R,3S)-3-benzyloxy-2-fluorotetradecanoyl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / 16 h / 25 °C

2: 60 percent / NaOH / ethanol; H₂O / 2 h / 50 °C

3: oxalyl chloride / CH₂Cl₂ / 1 h / 24 °C

4: 37.8 percent / triethylamine / CH₂Cl₂ / 15 h / 0 - 24 °C

With sodium hydroxide; oxalyl dichloride; trifluorormethanesulfonic acid; triethylamine; In ethanol; dichloromethane; water; 1: Etherification / 2: Hydrolysis / 3: Chlorination / 4: Acylation;
DOI:10.1246/bcsj.70.1149