3-[4-chloromethyl-2-(4-trifluoromethylphenyl)-5-thiazolyl]-1-(4-hydroxy-3-methylphenyl)propan-1-one

Base Information

Chemical Name:3-[4-chloromethyl-2-(4-trifluoromethylphenyl)-5-thiazolyl]-1-(4-hydroxy-3-methylphenyl)propan-1-one
CAS No.:915715-90-1
Molecular Formula:C₂₁H₁₇ClF₃NO₂S
Molecular Weight:439.886
Hs Code.:

Synonyms:3-[4-chloromethyl-2-(4-trifluoromethylphenyl)-5-thiazolyl]-1-(4-hydroxy-3-methylphenyl)propan-1-one

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Chemical Property of 3-[4-chloromethyl-2-(4-trifluoromethylphenyl)-5-thiazolyl]-1-(4-hydroxy-3-methylphenyl)propan-1-one

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Technology Process of 3-[4-chloromethyl-2-(4-trifluoromethylphenyl)-5-thiazolyl]-1-(4-hydroxy-3-methylphenyl)propan-1-one

There total 2 articles about 3-[4-chloromethyl-2-(4-trifluoromethylphenyl)-5-thiazolyl]-1-(4-hydroxy-3-methylphenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₃₆F₃NO₆S

: 915715-90-1
3-[4-chloromethyl-2-(4-trifluoromethylphenyl)-5-thiazolyl]-1-(4-hydroxy-3-methylphenyl)propan-1-one

Guidance literature:: C₃₆H₃₆F₃NO₆S; With hydrogenchloride; water; acetic acid; for 20h; Heating / reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 444612-94-6
5-(Chloromethyl)-4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

: 915715-90-1
3-[4-chloromethyl-2-(4-trifluoromethylphenyl)-5-thiazolyl]-1-(4-hydroxy-3-methylphenyl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 20 h / Heating / reflux

2.1: hydrogenchloride; water; acetic acid / 20 h / Heating / reflux

With hydrogenchloride; water; sodium hydride; acetic acid; In tetrahydrofuran;