1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one

Base Information

Chemical Name:1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one
CAS No.:85923-73-5
Molecular Formula:C₂₈H₃₄N₂O₆S
Molecular Weight:526.654
Hs Code.:

Synonyms:1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one

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Chemical Property of 1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one

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Technology Process of 1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one

There total 5 articles about 1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 80664-28-4
C₁₀H₁₆O₄

: 85923-50-8
(E)-1-<(p-methoxyphenyl)sulfonyl>-2-methyl-3-indole

: 85923-73-5
1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one

: 85923-72-4
cis-4a-ethyl-1,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1-<2,2-dimethoxyethyl>-2H-pyrido<3,2-c>carbazol-2-one

Guidance literature:: In chlorobenzene; at 135 ℃; for 2h;
DOI:10.1021/ja00352a037

Reference yield:

: 5416-80-8
2-methyl-1H-indole-3-carbaldehyde

: 85923-73-5
1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium hydride, 2.) imidazole / 1.) glyme, 20 deg C, 1.5 h, reflux, 15 min, 2.) 20 deg C, 15 h

2: CH₂Cl₂ / 15 h / 4 Angstroem molecular sieves

3: 28 percent / chlorobenzene / 2 h / 135 °C

With 1H-imidazole; sodium hydride; In dichloromethane; chlorobenzene;
DOI:10.1021/ja00352a037

Reference yield:

: 13722-73-1
4-ethylpent-4-enoic acid

: 85923-73-5
1-(2,2-Dimethoxy-ethyl)-4-[1-(4-methoxy-benzenesulfonyl)-2-methyl-1H-indol-3-yl]-3-(2-methylene-butyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

2: 28 percent / chlorobenzene / 2 h / 135 °C

With triethylamine; In dichloromethane; chlorobenzene;
DOI:10.1021/ja00352a037