(S)-N-((R)-1,1,1-trifluoro-2-(4-methoxyphenyl)-4-phenylbut-3-yn-2-yl)-2-methylprop-2-ylsulfinamide

Base Information

Chemical Name:(S)-N-((R)-1,1,1-trifluoro-2-(4-methoxyphenyl)-4-phenylbut-3-yn-2-yl)-2-methylprop-2-ylsulfinamide
CAS No.:1269535-42-3
Molecular Formula:C₂₁H₂₂F₃NO₂S
Molecular Weight:409.472
Hs Code.:

Synonyms:(S)-N-((R)-1,1,1-trifluoro-2-(4-methoxyphenyl)-4-phenylbut-3-yn-2-yl)-2-methylprop-2-ylsulfinamide

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Chemical Property of (S)-N-((R)-1,1,1-trifluoro-2-(4-methoxyphenyl)-4-phenylbut-3-yn-2-yl)-2-methylprop-2-ylsulfinamide

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Technology Process of (S)-N-((R)-1,1,1-trifluoro-2-(4-methoxyphenyl)-4-phenylbut-3-yn-2-yl)-2-methylprop-2-ylsulfinamide

There total 2 articles about (S)-N-((R)-1,1,1-trifluoro-2-(4-methoxyphenyl)-4-phenylbut-3-yn-2-yl)-2-methylprop-2-ylsulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 884595-98-6
C₁₃H₁₆F₃NO₂S

: 536-74-3
phenylacetylene

: 1269535-42-3
(S)-N-((R)-1,1,1-trifluoro-2-(4-methoxyphenyl)-4-phenylbut-3-yn-2-yl)-2-methylprop-2-ylsulfinamide

Guidance literature:: phenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

C₁₃H₁₆F₃NO₂S; With titanium(IV) isopropylate; In tetrahydrofuran; hexane; at -78 - 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetasy.2010.11.028

Reference yield:

: 711-38-6
4'-methoxy-2,2,2-trifluoroacetophenone

: 1269535-42-3
(S)-N-((R)-1,1,1-trifluoro-2-(4-methoxyphenyl)-4-phenylbut-3-yn-2-yl)-2-methylprop-2-ylsulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) isopropylate / hexane / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1016/j.tetasy.2010.11.028