(5R,7R)-1-[4-(benzyloxy)phenyl]-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}icos-1-yn-3-one

Base Information

• Chemical Name: (5R,7R)-1-[4-(benzyloxy)phenyl]-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}icos-1-yn-3-one
• CAS No.: 1220512-55-9
• Molecular Formula: C₄₅H₇₄O₄Si₂
• Molecular Weight: 735.251

Synonyms:(5R,7R)-1-[4-(benzyloxy)phenyl]-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}icos-1-yn-3-one

Chemical Property of (5R,7R)-1-[4-(benzyloxy)phenyl]-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}icos-1-yn-3-one

Chemical Property:

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Technology Process of (5R,7R)-1-[4-(benzyloxy)phenyl]-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}icos-1-yn-3-one

There total 1 articles about (5R,7R)-1-[4-(benzyloxy)phenyl]-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}icos-1-yn-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(3R,5R)-3,5-bis{[(tert-butyl)(dimethyl)silyl]oxy}-1-(morpholin-4-yl)octadecan-1-one (1220512-54-8) + [4-(benzyloxy)phenyl]acetylene (84284-70-8) → (5R,7R)-1-[4-(benzyloxy)phenyl]-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}icos-1-yn-3-one (1220512-55-9)

Guidance literature:

[4-(benzyloxy)phenyl]acetylene; With n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(3R,5R)-3,5-bis{[(tert-butyl)(dimethyl)silyl]oxy}-1-(morpholin-4-yl)octadecan-1-one; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.1055/s-0029-1217144

Reference yield: 88.0%

(5R,7R)-1-[4-(benzyloxy)phenyl]-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}icos-1-yn-3-one (1220512-55-9) → (5R,7R)-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}-1-(4-hydroxyphenyl)icosan-3-one (1220512-56-0)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In ethyl acetate; for 7h;

DOI:10.1055/s-0029-1217144

upstream raw materials:

(3R,5R)-3,5-bis{[(tert-butyl)(dimethyl)silyl]oxy}-1-(morpholin-4-yl)octadecan-1-one

[4-(benzyloxy)phenyl]acetylene

Downstream raw materials:

(5R,7R)-5,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}-1-(4-hydroxyphenyl)icosan-3-one

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