(2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine

Base Information

• Chemical Name: (2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine
• CAS No.: 1396010-05-1
• Molecular Formula: C₂₃H₂₅NO₂
• Molecular Weight: 347.457
• Mol file: 1396010-05-1.mol

Synonyms:(2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine

Chemical Property of (2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine

Chemical Property:

Purity/Quality:

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Technology Process of (2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine

There total 1 articles about (2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

propargyl bromide (106-96-7) + (2S,3S,4S)-3,4-bis(benzyloxy)-2-ethenylpyrrolidine → (2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine (1396010-05-1)

Guidance literature:

With potassium carbonate; In acetone; at 50 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0031-1290375

Reference yield: 71.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + (2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine (1396010-05-1) → (1S,2S,8bS)-1,2-bis(benzyloxy)-1,2,3,8,8a,8b-hexahydrocyclopenta[a]pyrrolizin-7(5H)-one

Guidance literature:

dicobalt octacarbonyl; (2S,3S,4S)-3,4-bis(benzyloxy)-1-(prop-2-ynyl)-2-vinylpyrrolidine; In dichloromethane; at 25 ℃; for 1h; Inert atmosphere;

With dimethyl sulfoxide; In toluene; at 80 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0031-1290375

upstream raw materials:

propargyl bromide