(S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine

Base Information

Chemical Name:(S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine
CAS No.:447460-52-8
Molecular Formula:C₂₁H₁₇F₄NO₄S₂
Molecular Weight:487.496
Hs Code.:

Synonyms:(S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine

Suppliers and Price of (S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine

Chemical Property:

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Technology Process of (S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine

There total 5 articles about (S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 447460-51-7
2,2,2-trifluoro-N-(1-{4-[2-(2-fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethyl)-acetamide

: 447460-52-8
(S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; water; for 3h;

Reference yield:

: 864872-81-1
2,2,2-trifluoro-N-{1-[4-(4-trifluoromethyl-benzenesulfonyl)-phenyl]-ethyl}-acetamide

: 447460-52-8
(S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: aq. LiOH / dioxane

With lithium hydroxide; n-butyllithium; In tetrahydrofuran; 1,4-dioxane; hexane;
DOI:10.1016/j.bmcl.2005.07.023

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 447460-52-8
(S)-1-{4-[2-(2-Fluoro-benzenesulfonyl)-4-trifluoromethyl-benzenesulfonyl]-phenyl}-ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: CH₂Cl₂ / 3 h / 20 °C

2.1: 46 g / dibromodimethyl hydantoin; methanesulfonic acid / CH₂Cl₂ / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: tetrahydrofuran; hexane

4.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

4.2: tetrahydrofuran; hexane / -78 - 20 °C

5.1: aq. LiOH / dioxane

With lithium hydroxide; n-butyllithium; methanesulfonic acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1016/j.bmcl.2005.07.023