(3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol

Base Information

Chemical Name:(3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol
CAS No.:1333325-49-7
Molecular Formula:C₂₄H₃₄O₃Si
Molecular Weight:398.618
Hs Code.:

Synonyms:(3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol

Suppliers and Price of (3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol

There total 18 articles about (3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333325-54-4
(S)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)-2-(2-oxoethyl)but-1-yl acetate

: 1333325-49-7
(3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2.1: 1H-imidazole; dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

4.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 3 h / -78 °C / Inert atmosphere

6.1: tetrahydrofuran; diethyl ether / 3 h / -78 °C / Inert atmosphere

With 1H-imidazole; dmap; dimethylsulfide borane complex; dihydrogen peroxide; sodium hexamethyldisilazane; toluene-4-sulfonic acid; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
DOI:10.1021/ol202265g

Reference yield:

: 1333325-55-5
(S)-2-(2-hydroxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate

: 1333325-49-7
(3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole; dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere

2.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

3.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 3 h / -78 °C / Inert atmosphere

5.1: tetrahydrofuran; diethyl ether / 3 h / -78 °C / Inert atmosphere

With 1H-imidazole; dmap; dihydrogen peroxide; sodium hexamethyldisilazane; toluene-4-sulfonic acid; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
DOI:10.1021/ol202265g

Reference yield:

: 1333325-47-5
(4S)-4-(2-tert-butyldiphenylsilyloxyethyl)dihydrofuran-2(3H)-one

: 1333325-49-7
(3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 3 h / -78 °C / Inert atmosphere

With sodium hexamethyldisilazane; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol202265g