Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester

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Chemical Name:Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester
CAS No.:714962-21-7
Molecular Formula:C₁₉H₂₂O₆S
Molecular Weight:378.446
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester

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Chemical Property of Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester

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Technology Process of Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester

There total 6 articles about Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 758695-37-3
Toluene-4-sulfonic acid 2-((2S,4R,5S)-2,5-dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-phenyl ester

: 714962-21-7
Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1016/j.tetlet.2004.06.065

Reference yield:

: 184110-36-9
(2S,1'R/S)-2-(1'-Ethoxyethoxy)propanal

: 714962-21-7
Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Me₂CHMgCl / CH₂Cl₂ / 0.5 h / 0 °C

1.2: CH₂Cl₂ / 4.5 h / 20 - 40 °C / ultrasonication

2.1: camphorsulfonic acid; CH₃CH(OEt)2 / 0.5 h / 20 °C

3.1: K₂CO₃ / acetone / 7 h / 20 °C

4.1: 44 percent / titanium(IV) chloride / CH₂Cl₂ / 2 h / -78 °C

With diethyl acetal; camphor-10-sulfonic acid; isopropylmagnesium chloride; titanium tetrachloride; potassium carbonate; In dichloromethane; acetone;
DOI:10.1016/j.tetlet.2004.06.065

Reference yield:

: 150-76-5
4-methoxy-phenol

: 714962-21-7
Toluene-4-sulfonic acid (1S,3S,4R)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Me₂CHMgCl / CH₂Cl₂ / 0.5 h / 0 °C

1.2: CH₂Cl₂ / 4.5 h / 20 - 40 °C / ultrasonication

2.1: camphorsulfonic acid; CH₃CH(OEt)2 / 0.5 h / 20 °C

3.1: K₂CO₃ / acetone / 7 h / 20 °C

4.1: 44 percent / titanium(IV) chloride / CH₂Cl₂ / 2 h / -78 °C

With diethyl acetal; camphor-10-sulfonic acid; isopropylmagnesium chloride; titanium tetrachloride; potassium carbonate; In dichloromethane; acetone;
DOI:10.1016/j.tetlet.2004.06.065