2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide

Base Information

• Chemical Name: 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide
• CAS No.: 643745-03-3
• Molecular Formula: C₂₇H₂₃ClN₄O₃
• Molecular Weight: 486.958

Synonyms:2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide

Chemical Property of 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide

There total 8 articles about 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-methoxymethoxy-biphenyl-3-yl}-N,N-dimethyl-acetamide → 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide (643745-03-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol;

DOI:10.1016/j.tetlet.2003.09.139

Reference yield:

4-amino-2-chlorobenzonitrile (20925-27-3) → 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide (643745-03-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 48 percent / N-iodosuccinimide / acetic acid

2: DMAP / tetrahydrofuran

3: NaOH / H₂O; tetrahydrofuran; ethanol

4: NH₂OH / H₂O; ethanol / 1.5 h / Heating

5: i-Pr₂NEt / CH₂Cl₂ / 0 °C

6: Bu₄NF / tetrahydrofuran

7: 72 percent / NEt₃; CuI / Pd(PPh₃)2Cl₂ / dimethylformamide

8: Bu₄NOH / H₂O; tetrahydrofuran / Heating

9: 100 percent / HCl / dioxane; methanol

With hydrogenchloride; dmap; sodium hydroxide; N-iodo-succinimide; copper(l) iodide; tetrabutyl ammonium fluoride; tetra(n-butyl)ammonium hydroxide; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; 7: Sonogashira coupling;

DOI:10.1016/j.tetlet.2003.09.139

Reference yield:

4-amino-2-chloro-5-iodobenzonitrile (380241-58-7) → 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide (643745-03-3)

Guidance literature:

Multi-step reaction with 8 steps

1: DMAP / tetrahydrofuran

2: NaOH / H₂O; tetrahydrofuran; ethanol

3: NH₂OH / H₂O; ethanol / 1.5 h / Heating

4: i-Pr₂NEt / CH₂Cl₂ / 0 °C

5: Bu₄NF / tetrahydrofuran

6: 72 percent / NEt₃; CuI / Pd(PPh₃)2Cl₂ / dimethylformamide

7: Bu₄NOH / H₂O; tetrahydrofuran / Heating

8: 100 percent / HCl / dioxane; methanol

With hydrogenchloride; dmap; sodium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; tetra(n-butyl)ammonium hydroxide; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 6: Sonogashira coupling;

DOI:10.1016/j.tetlet.2003.09.139

upstream raw materials:

4-amino-2-chlorobenzonitrile

4-amino-2-chloro-5-iodobenzonitrile

(5-chloro-4-cyano-2-iodo-phenyl)-carbamic acid tert-butyl ester

[5-chloro-2-iodo-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 643745-03-3 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send