methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate

Base Information

Chemical Name:methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate
CAS No.:1446246-88-3
Molecular Formula:C₂₄H₂₆N₆O₅S
Molecular Weight:510.574
Hs Code.:

Synonyms:methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate

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Chemical Property of methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate

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Technology Process of methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate

There total 11 articles about methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446246-90-7
methyl 4-[({[4-(aminocarbonyl)-3-(4-aminophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoate

: 622-58-2,374675-64-6
p-Tolylisocyanate

: 1446246-88-3
methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃; for 21h;

Reference yield:

: 605661-26-5
2-[amino(4-nitrophenyl)methylene]malononitrile

: 1446246-88-3
methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: O,O-Diethyl hydrogen phosphorodithioate / ethanol; water / 100 °C / Inert atmosphere

2.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

3.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

3.2: 20 °C

4.1: sulfuric acid / 1.83 h / 45 °C

4.2: Cooling with ice

5.1: sodium hydroxide / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

7.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 4137.29 Torr / Autoclave

8.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 21 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium carbonate; O,O-Diethyl hydrogen phosphorodithioate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 909028-96-2
3-amino-3-(4-nitrophenyl)-2-thioformamidoacrylonitrile

: 1446246-88-3
methyl 4-{[({4-(aminocarbonyl)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-5-yl}amino)carbonyl]amino}butanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

2.2: 20 °C

3.1: sulfuric acid / 1.83 h / 45 °C

3.2: Cooling with ice

4.1: sodium hydroxide / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 4137.29 Torr / Autoclave

7.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 21 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;