1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one

Base Information

Chemical Name:1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one
CAS No.:138900-50-2
Molecular Formula:C₂₉H₃₄ClFN₄O
Molecular Weight:509.067
Hs Code.:

Synonyms:1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one

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Chemical Property of 1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one

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Technology Process of 1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one

There total 7 articles about 1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 138900-50-2
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: TFA, AcOH / 0.5 h / Heating

2: H₂, AcOH / PtO₂ / ethanol / 16 h / 1900 - 2280 Torr

3: K₂CO₃, KI / various solvent(s) / 16 h / Heating

With hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; platinum(IV) oxide; In ethanol;
DOI:10.1021/jm00084a014

Reference yield:

: 138900-22-8
1-(4-fluorophenyl)-5-chloroindole

: 138900-50-2
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: TFA, AcOH / 0.5 h / Heating

2: H₂, AcOH / PtO₂ / ethanol / 16 h / 1900 - 2280 Torr

3: K₂CO₃, KI / various solvent(s) / 16 h / Heating

With hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; platinum(IV) oxide; In ethanol;
DOI:10.1021/jm00084a014

Reference yield:

: 948553-95-5
5-Chloro-1-(4-fluoro-phenyl)-2,3-dihydro-1H-indol-3-ol

: 138900-50-2
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-3-cyclopentyl-imidazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: TFA / CH₂Cl₂ / 1 h / Heating

2: TFA, AcOH / 0.5 h / Heating

3: H₂, AcOH / PtO₂ / ethanol / 16 h / 1900 - 2280 Torr

4: K₂CO₃, KI / various solvent(s) / 16 h / Heating

With hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; platinum(IV) oxide; In ethanol; dichloromethane;
DOI:10.1021/jm00084a014