3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester

Base Information

Chemical Name:3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester
CAS No.:871980-67-5
Molecular Formula:C₃₅H₃₇ClF₄N₆O₄S
Molecular Weight:749.229
Hs Code.:

3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester

Synonyms:3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester

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Chemical Property of 3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester

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Technology Process of 3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester

There total 12 articles about 3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: [5-chloro-2-fluoro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetic acid

: 3-[2-[(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester dihydrochloride

: 871980-67-5
3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester

Guidance literature:: [5-chloro-2-fluoro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetic acid; 3-[2-[(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester dihydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 14h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 61.0%

: 871980-67-5
3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester

Guidance literature:

Reference yield:

: 871979-66-7
((4R)-acetoxy-1-tert-butoxycarbonyl-(4R)-(2S)-pyrrolidinyl)carboxylic acid benzyl ester

: 871980-67-5
3-[2-[1-[5-chloro-2-fluoro-4-(1-methyl-3-indolylcarbonylamino)phenylacetyl]-(4S)-[1-(4-(2,2,2-trifluoro)ethyl)piperazinyl]-(2S)-pyrrolidinyl]-5-thiazolyl]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium hydroxide on carbon / ethanol / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

3.1: Lawessons reagent / toluene / 1 h / 90 °C

4.1: potassium carbonate / methanol / 1 h / 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C

5.2: 0.5 h / -78 - 0 °C

5.3: 0.5 h

6.1: sodium triacetoxyborohydride / 1,2-dichloro-ethane / 32 h

6.2: 0.5 h

7.1: hydrogenchloride / 1,4-dioxane / 13 h

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 14 h / 20 °C

With Lawessons reagent; hydrogenchloride; oxalyl dichloride; sodium triacetoxyborohydride; hydrogen; potassium carbonate; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium hydroxide on carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;