(S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one

Base Information

Chemical Name:(S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one
CAS No.:1260612-80-3
Molecular Formula:C₃₇H₆₂O₇Si
Molecular Weight:646.981
Hs Code.:

(S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one

Synonyms:(S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one

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Chemical Property of (S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one

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Technology Process of (S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one

There total 9 articles about (S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1260612-79-0
(3S,4R,10S)-1-(4-methoxybenzyloxy)-3,4,10-trimethyl-3-(2-(2-methyl-(1,3)dioxolan-2-yl)ethyl)-10-triethylsilanyloxytetradeca-6,13-diene-2,8-dione

: 1260612-80-3
(S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one

Guidance literature:: With (triphenylphosphine)copper hydride hexamer; In toluene; at -40 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol1026816

Reference yield:

: 1260612-67-6
(S)-ethyl 3,7-dimethyl-3-(triethylsilyloxy)oct-6-enoate

: 1260612-80-3
(S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxygen; ozone / dichloromethane / -78 °C

1.2: -78 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

2.2: 0.5 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

4.2: 0.25 h / 0 °C

5.1: (triphenylphosphine)copper hydride hexamer / toluene / 3 h / -40 - 20 °C / Inert atmosphere

With n-butyllithium; (triphenylphosphine)copper hydride hexamer; oxygen; sodium hexamethyldisilazane; ozone; In tetrahydrofuran; hexane; dichloromethane; toluene; 2.2: Wittig reaction / 4.2: Horner-Wadsworth-Emmons olefination / 5.1: Aldol condensation;
DOI:10.1021/ol1026816

Reference yield:

: 1260612-69-8
(S)-ethyl 3-methyl-3-(triethylsilyloxy)hept-6-enoate

: 1260612-80-3
(S)-1-(1R,2R,3S,4R)-2-hydroxy-2-((4-methoxybenzyloxy)methyl)-3,4-dimethyl-3-(2-(2-methyl-1,3-dioxolan-2-yl)ethylcyclohexyl)-3-methyl-3-(triethylsilanyloxy)hept-6-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.25 h / 0 °C

3.1: (triphenylphosphine)copper hydride hexamer / toluene / 3 h / -40 - 20 °C / Inert atmosphere

With n-butyllithium; (triphenylphosphine)copper hydride hexamer; sodium hexamethyldisilazane; In tetrahydrofuran; hexane; toluene; 2.2: Horner-Wadsworth-Emmons olefination / 3.1: Aldol condensation;
DOI:10.1021/ol1026816