3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

Base Information

Chemical Name:3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile
CAS No.:154389-12-5
Molecular Formula:C₂₁H₁₉BrFN₃
Molecular Weight:412.304
Hs Code.:

Synonyms:3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

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Technology Process of 3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

There total 2 articles about 3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 154389-14-7
3-<2-(4-fluorophenyl)-5-isopropyl-3-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

: 154389-12-5
3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: 151105-85-0
1-(4-fluorophenyl)-5-methyl-2-(4-pyridyl)-1,4-hexanedione

: 154389-12-5
3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / glacial acetic acid / 3 h / Heating

2: 72 percent / N-bromosuccinimide / dimethylformamide / 5 h / 20 °C

With N-Bromosuccinimide; acetic acid; In N,N-dimethyl-formamide;

Reference yield: 42.0%

: 154389-12-5
3-<3-bromo-5-(4-fluorophenyl)-2-isopropyl-4-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

: 3-<2-(4-fluorophenyl)-1,5-dihydro-2-hydroxy-4-isopropyl-5-oxo-3-(4-pyridyl)-1H-pyrrol-1-yl>propionitrile

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In N,N-dimethyl-formamide; at 20 ℃; for 48h; Product distribution; Mechanism; novel oxidative rearrangement;