N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide

Base Information

Chemical Name:N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide
CAS No.:1569736-06-6
Molecular Formula:C₁₈H₂₁NO₂S₂
Molecular Weight:347.502
Hs Code.:

Synonyms:N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide

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Chemical Property of N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide

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Technology Process of N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide

There total 5 articles about N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 527-72-0
2-thiophenylcarboxylic acid

: 1343811-07-3
3-[(cyclopentylsulfanyl)methyl]-4-methoxyaniline

: 1569736-06-6
N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide

Guidance literature:: 2-thiophenylcarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

3-[(cyclopentylsulfanyl)methyl]-4-methoxyaniline; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/ml400519h

Reference yield:

: 100-17-4
para-methoxynitrobenzene

: 1569736-06-6
N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; sodium bromide; acetic acid / 3 h / 85 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

3.1: acetic acid; iron / 7 h / 30 - 60 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 3 h / 20 °C

With sulfuric acid; iron; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bromide; In N,N-dimethyl-formamide;
DOI:10.1021/ml400519h

Reference yield:

: 1569735-46-1
2-[(cyclopentylsulfanyl)methyl]-1-methoxy-4-nitrobenzene

: 1569736-06-6
N-{3-[(cyclopentylsulfanyl)methyl]-4-methoxyphenyl}thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; iron / 7 h / 30 - 60 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 3 h / 20 °C

With iron; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ml400519h