Technology Process of 9-oxo-9H-pyrrolo[1,2-a]indole-5-carboxylic acid (2-amino-4-fluorophenyl)amide
There total 4 articles about 9-oxo-9H-pyrrolo[1,2-a]indole-5-carboxylic acid (2-amino-4-fluorophenyl)amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
9-oxo-9H-pyrrolo[1,2-a]indole-5-carboxylic acid;
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Inert atmosphere;
4-fluoro-1,2-phenylenediamine;
In
tetrahydrofuran;
for 72h;
With
sodium hydrogencarbonate;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron tribromide / dichloromethane / 2 h / 20 °C
2.1: water; lithium hydroxide monohydrate / methanol / 3 h / Reflux
2.2: pH 3
3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3.2: 72 h
With
lithium hydroxide monohydrate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
boron tribromide;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 16 h / 50 °C / 1500.15 Torr
2.1: water; lithium hydroxide monohydrate / methanol / 3 h / Reflux
2.2: pH 3
3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3.2: 72 h
With
lithium hydroxide monohydrate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine;
1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
