1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin

Base Information

Chemical Name:1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin
CAS No.:141282-52-2
Molecular Formula:C₃₂H₃₄N₂O₇
Molecular Weight:558.631
Hs Code.:

Synonyms:1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin

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Chemical Property of 1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin

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Technology Process of 1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin

There total 5 articles about 1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 64750-94-3
1-(2',3'-Dideoxy-β-D-erythro-hex-2'-enopyranosyl)thymine

: 141282-52-2
1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin

Guidance literature:: With pyridine; dmap; triethylamine; for 4.5h; Ambient temperature;
DOI:10.1002/hlca.19920750503

Reference yield:

: 102794-34-3
1-(4',6'-O-diacetyl-2',3'-dideoxy-β-D-erythro-hex-2-enopyranosyl)thymidine

: 141282-52-2
1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol / 2 h / 1551.4 Torr / Ambient temperature

2: NH₃/CH₃OH / 16 h / Ambient temperature

3: 80 percent / pyridine / 18 h / Ambient temperature

With pyridine; methanol; ammonia; hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 141282-52-2
1-<2',3'-Dideoxy-6'-O-<(4,4'-dimethoxytriphenyl)methyl>-β-D-glucopyranosyl>thymin

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) hexamethyldisilazane, ammonium sulfate, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) reflux, 2.) acetonitrile, r.t., 1 h

2: H₂ / 10percent Pd/C / methanol / 2 h / 1551.4 Torr / Ambient temperature

3: NH₃/CH₃OH / 16 h / Ambient temperature

4: 80 percent / pyridine / 18 h / Ambient temperature

With pyridine; methanol; ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; ammonia; hydrogen; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In methanol;