1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one

Base Information

Chemical Name:1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one
CAS No.:1613082-53-3
Molecular Formula:C₂₃H₂₁N₇O₃
Molecular Weight:443.465
Hs Code.:

Synonyms:1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one

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Chemical Property of 1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one

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Technology Process of 1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one

There total 4 articles about 1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1613082-51-1
C₁₅H₁₀ClN₃O₃

: 34803-68-4
1-(pyrazin-2-yl)piperazine

: 1613082-53-3
1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one

Guidance literature:: With potassium carbonate; In acetonitrile; for 4h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2014.04.047

Reference yield:

: 14508-49-7
2-chloropyrazin

: 1-(4-nitrobenzyl)-3-(piperazin-1-yl)quinoxalin-2(1H)-one

: 1613082-53-3
1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 110 ℃; for 4h;
DOI:10.1021/acs.joc.7b00464

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1613082-53-3
1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl)piperazin-1-yl)quinoxalin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 75 °C

2: potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2014.04.047