1⁽²⁾H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide

Base Information

• Chemical Name: 1⁽²⁾H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide
• CAS No.: 70977-49-0
• Molecular Formula: C₁₂H₁₀N₆O₃
• Molecular Weight: 286.25
• Mol file: 70977-49-0.mol

Synonyms:1⁽²⁾H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide

Chemical Property of 1⁽²⁾H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1⁽²⁾H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide

There total 5 articles about 1⁽²⁾H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide (70977-99-0) → 1(2)H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide (70977-49-0)

Guidance literature:

With trifluoroacetic acid; for 0.5h; Heating;

DOI:10.1021/jm00154a019

Reference yield:

4-hydroxy-3-propanolylbenzonitrile (70978-58-4) → 1(2)H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide (70977-49-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 40 percent / conc. HNO₃, conc. H₂SO₄ / -20 °C

2: 70 percent / H₂ / 5percent Pd/C / ethanol

3: pyridine / CH₂Cl₂ / 1 h / 20 °C

4: 80 percent / CF₃COOH / 0.5 h / Heating

With pyridine; sulfuric acid; hydrogen; nitric acid; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00154a019

Reference yield:

5-cyano-2-hydroxy-3-nitropropiophenone (70978-55-1) → 1(2)H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide (70977-49-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / H₂ / 5percent Pd/C / ethanol

2: pyridine / CH₂Cl₂ / 1 h / 20 °C

3: 80 percent / CF₃COOH / 0.5 h / Heating

With pyridine; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00154a019

upstream raw materials:

1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 5-cyano-2-hydroxy-3-propionyl-anilide

4-hydroxy-3-propanolylbenzonitrile

3-amino-5-cyano-2-hydroxypropiophenone

5-cyano-2-hydroxy-3-nitropropiophenone