1-Piperidinecarboxylicacid,4-hydroxy-2-methyl-,1,1-dimethylethylester,(2R,4S)-(9CI)

Base Information

• Chemical Name: 1-Piperidinecarboxylicacid,4-hydroxy-2-methyl-,1,1-dimethylethylester,(2R,4S)-(9CI)
• CAS No.: 790668-06-3
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.293
• Mol file: 790668-06-3.mol

Synonyms:(2R,4S)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate

Chemical Property of 1-Piperidinecarboxylicacid,4-hydroxy-2-methyl-,1,1-dimethylethylester,(2R,4S)-(9CI)

Chemical Property:

• Boiling Point: 301.4±35.0 °C(Predicted)
• PKA: 14.82±0.40(Predicted)
• Density: 1.067±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(2R,4S)-1-Boc-2-methyl-4-hydroxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylicacid,4-hydroxy-2-methyl-,1,1-dimethylethylester,(2R,4S)-(9CI)

There total 2 articles about 1-Piperidinecarboxylicacid,4-hydroxy-2-methyl-,1,1-dimethylethylester,(2R,4S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(2R)-2-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (790667-43-5) → tert-butyl (2R,4R)-4-hydroxy-2-methylpiperidine-1-carboxylate (790667-44-6,152491-46-8) + (2R,4S)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate (790668-06-3,152491-46-8)

Guidance literature:

With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate (190906-92-4) → tert-butyl (2R,4R)-4-hydroxy-2-methylpiperidine-1-carboxylate (790667-44-6,152491-46-8) + (2R,4S)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate (790668-06-3,152491-46-8) + (2S,4R)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate (790667-91-3,152491-46-8) + tert-butyl (2S,4S)-4-hydroxy-2-methyl-piperidine-1-carboxylate (790667-99-1,152491-46-8)

Guidance literature:

tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate; With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

With methanol; water; at 20 ℃; for 1h;

Reference yield:

(2R,4S)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate (790668-06-3,152491-46-8) + 2-fluoro-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile → (2R,4S)-tert-butyl 4-(2-cyano-4-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)phenoxy)-2-methylpiperidine-1-carboxylate

Guidance literature:

(2R,4S)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate; With potassium tert-butylate; In 2-methyltetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

2-fluoro-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile; In 2-methyltetrahydrofuran; at 20 - 60 ℃;

upstream raw materials:

(2R)-2-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate

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